Location
Student Center
Document Type
Poster
Start Date
19-8-2025 2:30 PM
End Date
19-8-2025 3:30 PM
Description
The growing demand for real-time, precise, cancer diagnostics and treatment has driven the development of targeted near-infrared (NIR) fluorescent biosensors. Traditional visible-range fluorophores, such as Boron-dipyrromethene (BODIPY) dyes are well-known for their high quantum yields, photostability, biocompatibility, and sharp absorption and emission peaks, making them widely used in fluorescence imaging (Nisar and Sui). However, Cyanine dyes offer some advantages over visible-range dyes, such as deeper tissue penetration due to their near-infrared (NIR) absorption and emission, significantly reduced background autofluorescence, and improved signal-to- noise ratios in vivo (Zhang et al.). This project explores the synthesis and characterization of the NIR fluorescent biosensor Cyanine-7-2, which is designed to improve imaging in deep biological tissues. The research focus is on developing near-IR dyes that can be conjugated to cancer- targeting biomolecules for enhanced specificity and targeted drug delivery in cancer cell imaging. This work contributes to the development of more effective imaging tools for early cancer detection, diagnosis, and real-time monitoring, potentially enhancing clinical outcomes through earlier intervention and reduced invasiveness.
Included in
Synthesis and Characterization of Near-Infrared Fluorescent Dye Cy7-2 for Targeted Cancer Imaging
Student Center
The growing demand for real-time, precise, cancer diagnostics and treatment has driven the development of targeted near-infrared (NIR) fluorescent biosensors. Traditional visible-range fluorophores, such as Boron-dipyrromethene (BODIPY) dyes are well-known for their high quantum yields, photostability, biocompatibility, and sharp absorption and emission peaks, making them widely used in fluorescence imaging (Nisar and Sui). However, Cyanine dyes offer some advantages over visible-range dyes, such as deeper tissue penetration due to their near-infrared (NIR) absorption and emission, significantly reduced background autofluorescence, and improved signal-to- noise ratios in vivo (Zhang et al.). This project explores the synthesis and characterization of the NIR fluorescent biosensor Cyanine-7-2, which is designed to improve imaging in deep biological tissues. The research focus is on developing near-IR dyes that can be conjugated to cancer- targeting biomolecules for enhanced specificity and targeted drug delivery in cancer cell imaging. This work contributes to the development of more effective imaging tools for early cancer detection, diagnosis, and real-time monitoring, potentially enhancing clinical outcomes through earlier intervention and reduced invasiveness.