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Cancer cells--Proliferation; Breast--Cancer--Hormone therapy


Cell proliferation of a mammary adenocarcinoma cell line, CAMA-1. is affected by a number of steroid hormones and prolactin in long-term cultures. Estrogenic compounds stimulate cell growth while antiestrogenic compounds inhibit it. Prolactin can synergize the estrogenic effect. Progesterone, glucocorticoid or androgen reduce cell proliferation. Dihydrotestosterone is a very potent inhibitor,- effective at as low as 10 nM, and its effect is independent of estrogen action. Cortisol is a less effective inhibitor at concentrations below 10 nM; at these levels cortisol exhibits a slight inhibition which appears to be unrelated to estrogenic action. However, at higher concentrations, cortisol markedly reduces cell division and drastically diminishes the stimulatory effect of estrogen on cell growth. The precise mechanisms of hormone actions on cell proliferation remain to be explored.

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