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Hematopoietic stem cells; Irradiation


It was found that isologous spleen cells injected into heavily irradiated recipients produced spleen nodules. The number of nodules or colony-farming-units (CFU) varied with cell dose, and were presumably clonal descendants of a single progenitor cell. The properties of the spleen and bone marrow CFU were compared and it was found that although present in greatly differing concentration, the radiation response and morphological features were similar.

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