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Biosynthesis; Cholesterol--Synthesis


The purpose of this paper is to summarize the results of my research on the enzymic steps of cholesterol biosynthesis (Dempsey, 1962; 1964; 1965; Dempsey, Seaton, and Trockmon,1963; Dempsey, Seaton, Sanford, and Trockmon,19640; Dempsey, Seaton, Schroepfer, and Trackman, 19646.2 These data were obtained by use of an enzyme system isolated from rat liver homogenates. The findings have elucidated the pathways of and cofactor requirements for cholesterol synthesis from naturally occurring sterol precursors.

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