"A New Experimental Approach to the Evaluation of the Effect of Narcoti" by Charles H. Pierce, Richard B. McHugh et al.

Article Title

A New Experimental Approach to the Evaluation of the Effect of Narcotic Analgesics Upon Respiratory Function

Authors

Charles H. Pierce, University of Minnesota, Minneapolis
Richard B. McHugh, University of Minnesota, Minneapolis
Raymond N. Bieter, University of Minnesota, Minneapolis

Document Type

Article

Publication Date

1965

Keywords

Narcotics; Analgesics; Respiratory organs

Abstract

Experimental models often used to study the effects of drugs upon respiratory function employ anesthetized animals. The present study eliminated the possible interference of anesthetics by using dogs altered only by a Permanent lracheostomy. Respiratory function was evaluated by determining end-expiratory (alveolar) CO, tension. The experimental design, an extension of the cross-over type, permitted the estimation of possible residual effects of the drugs applied in sequence la the same animals. Morphine Sulfate increasingly caused on elevation in alveolar pCO, while Meperidine HCl had no such effect. An antitussive meperidine derivative, WIN 13187, had respiratory effects similar to meperidine.

First Page

117

Last Page

120

Recommended Citation

Pierce, C. H., McHugh, R. B., & Bieter, R. N. (1965). A New Experimental Approach to the Evaluation of the Effect of Narcotic Analgesics Upon Respiratory Function. Journal of the Minnesota Academy of Science, Vol. 32 No.2, 117-120.
Retrieved from https://digitalcommons.morris.umn.edu/jmas/vol32/iss2/13

Primo Type

Article

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