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Mice as laboratory animals; Circadian rhythms--Effect of chemicals on; Acetylcholine; Mice--Mortality


The detection of a circadian ( about 24- hour) susceptibility-resistance cycle to acetylcholine by spot checks on mortality from this agent will be here presented. The study was done under conditions standardized to some extent for 24-hour routine-synchronized circadian system analysis ( 1). Sampling was limited to only two time points along the 24-hour scale. Hence, results represent a spot check rather than a circadian map. The conclusions to be drawn from these data have been confirmed, in the interim, with more frequent sampling. The data to be reported constitute further evidence that circadian system structure (2) involves significant and predictable changes in the reactivity of organisms to various agents.

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